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KMID : 1025520110530010015
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Journal of Animal Science and Technology
2011 Volume.53 No. 1 p.15 ~ p.22
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Association of Single Nucleotide Polymorphism(SNP) in the PGK 2 Gene with Growth Traits in Pigs
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Jang Hong-Chul
Kim Sang-Wook
Lim Da-Jeong
Kim Jae-Young
Cho Kyu-Ho
Kim Myong-Jik
Lee Ji-Woong
Choi Bong-Hwan
Kim Tae-Hun
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Abstract
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The purpose of this study was to analyse of association between growth traits and single nucleotide polymorphisms(SNPs) polymorphism of phosphoglycerate kinase 2(PGK 2) gene in pigs. The birth weight of piglet influences on weaning weight and survival rate that are import economic traits in pig industry. Also, these growth traits are representative factor to decrease a period getting to marketing weight as well as growth rate in pig. The PGK 2 is an isozyme that catalyzes the first ATP-generating step in the glycolytic pathwayand important enzyme related with energy metabolism. Twenty of SNPs were discoveredby genome structure analysis that compares the sequence on promoter and transcription region of PGK 2 gene in porcine chromosome 7. An association between PGK 2 SNPs and growth traits was analyzed in F2 reciprocal-crossbred population between korean native pig(KNP) and Landrace. Association analysis indicated that polymorphism of the PGK 2 gene promoter region has significant effects on weight at birth(p<0.01) and weight at 3 weeks of age(p<0.0001). These results suggest that PGK 2 gene polymorphism was associated with energy metabolism and physiological function of growth in pig.
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KEYWORD
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PGK 2, SNP, Pig, Birth weight, 3 weeks weight
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